Apoptosis (from Ancient Greek ἀπόπτωσις, apóptōsis, "falling off") is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, chromosomal DNA fragmentation, and global[vague] mRNA decay. The average adult human loses between 50 and 70 billion cells each day due to apoptosis. For an average human child between the ages of 8 and 14, approximately 20–30 billion cells die per day.
In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, apoptosis is a highly regulated and controlled process that confers advantages during an organism's life cycle. For example, the separation of fingers and toes in a developing human embryo occurs because cells between the digits undergo apoptosis. Unlike necrosis, apoptosis produces cell fragments called apoptotic bodies that phagocytic cells are able to engulf and remove before the contents of the cell can spill out onto surrounding cells and cause damage to them.
Because apoptosis cannot stop once it has begun, it is a highly regulated process. Apoptosis can be initiated through one of two pathways. In the intrinsic pathway the cell kills itself because it senses cell stress, while in the extrinsic pathway the cell kills itself because of signals from other cells. Weak external signals may also activate the intrinsic pathway of apoptosis. Both pathways induce cell death by activating caspases, which are proteases, or enzymes that degrade proteins. The two pathways both activate initiator caspases, which then activate executioner caspases, which then kill the cell by degrading proteins indiscriminately.
Electromagnetic fields (EMF) are a combination of electric and magnetic field forces. They are generated either by nature or by human activities.
Natural electromagnetic fields are, for example, Earth’s static magnetic field to which we are constantly exposed, or electrical fields created by electrical discharges in the clouds, or by static electricity produced when two objects are rubbed against each other, not to mention electrical and magnetic fields that are created with lightning and so on.
Manmade electromagnetic fields are generated for example by sources producing SLF (extreme low frequency) such as electrical powerlines, cables and home appliances, as well as by sources of microwave radiation such as Low frequency radiation
Extreme low frequency, between 3 and 30 Hz. Example: human brain frequencies
Extreme high frequencies, “millimeter wave band”, between 110 to 300 GHz Example: 5G, fire-control radar, airport security scanners, short range wireless networks, weapon system LRAD, and scientific research.
In mathematics, a fractal is a self-similar subset of Euclidean space whose fractal dimension strictly exceeds its topological dimension. Fractals appear the same at different levels, as illustrated in successive magnifications of the Mandelbrot set; because of this, fractals are encountered ubiquitously in nature. Fractals exhibit similar patterns at increasingly small scales called self-similarity, also known as expanding symmetry or unfolding symmetry; if this replication is exactly the same at every scale, as in the Menger sponge, it is called affine self-similar. Fractal geometry lies within the mathematical branch of measure theory.
One way that fractals are different from finite geometric figures is the way in which they scale. Doubling the edge lengths of a polygon multiplies its area by four, which is two (the ratio of the new to the old side length) raised to the power of two (the dimension of the space the polygon resides in). Likewise, if the radius of a sphere is doubled, its volume scales by eight, which is two (the ratio of the new to the old radius) to the power of three (the dimension that the sphere resides in). However, if a fractal's one-dimensional lengths are all doubled, the spatial content of the fractal scales by a power that is not necessarily an integer. This power is called the fractal dimension of the fractal, and it usually exceeds the fractal's topological dimension.
In biology, homeostasis is the state of steady internal, physical, and chemical conditions maintained by living systems. This dynamic state of equilibrium is the condition of optimal functioning for the organism and includes many variables, such as body temperature and fluid balance, being kept within certain pre-set limits (homeostatic range). Other variables include the pH of extracellular fluid, the concentrations of sodium, potassium and calcium ions, as well as that of the blood sugar level, and these need to be regulated despite changes in the environment, diet, or level of activity. Each of these variables is controlled by one or more regulators or homeostatic mechanisms, which together maintain life.
Homeostasis is brought about by a natural resistance to change when already in the optimal conditions, and equilibrium is maintained by many regulatory mechanisms. All homeostatic control mechanisms have at least three interdependent components for the variable being regulated: a receptor, a control center, and an effector. The receptor is the sensing component that monitors and responds to changes in the environment, either external or internal. Receptors include thermoreceptors, and mechanoreceptors. Control centers include the respiratory center, and the renin–angiotensin system. An effector is the target acted on, to bring about the change back to the normal state. At the cellular level, receptors include nuclear receptors that bring about changes in gene expression through up-regulation or down-regulation, and act in negative feedback mechanisms. An example of this is in the control of bile acids in the liver.
Microwave radiation includes the following frequency ranges : VHF, UHF, SHF and EHF. See glossary for information.
Reactive nitrogen species (RNS) are a family of antimicrobial molecules derived from nitric oxide (•NO) and superoxide (O2•−) produced via the enzymatic activity of inducible nitric oxide synthase 2 (NOS2) and NADPH oxidase respectively. NOS2 is expressed primarily in macrophages after induction by cytokines and microbial products, notably interferon-gamma (IFN-γ) and lipopolysaccharide (LPS).
Reactive nitrogen species act together with reactive oxygen species (ROS) to damage cells, causing nitrosative stress. Therefore, these two species are often collectively referred to as ROS/RNS. Reactive nitrogen species are also continuously produced in plants as by-products of aerobic metabolism or in response to stress.
Oxidative stress is an imbalance between free radicals and antioxidants in your body. Free radicals are oxygen-containing molecules with an uneven number of electrons. The uneven number allows them to easily react with other molecules. Free radicals can cause large chain chemical reactions in your body because they react so easily with other molecules. These reactions are called oxidation. They can be beneficial or harmful. Antioxidants are molecules that can donate an electron to a free radical without making themselves unstable. This causes the free radical to stabilize and become less reactive.
Oxidation is a normal and necessary process that takes place in your body. Oxidative stress, on the other hand, occurs when there’s an imbalance between free radical activity and antioxidant activity. When functioning properly, free radicals can help fight off pathogens. Pathogens lead to infections.
Paramagnetism is a form of magnetism whereby some materials are weakly attracted by an externally applied magnetic field, and form internal, induced magnetic fields in the direction of the applied magnetic field. In contrast with this behavior, diamagnetic materials are repelled by magnetic fields and form induced magnetic fields in the direction opposite to that of the applied magnetic field. Paramagnetic materials include most chemical elements and some compounds; they have a relative magnetic permeability slightly greater than 1 (i.e., a small positive magnetic susceptibility) and hence are attracted to magnetic fields. The magnetic moment induced by the applied field is linear in the field strength and rather weak. It typically requires a sensitive analytical balance to detect the effect and modern measurements on paramagnetic materials are often conducted with a SQUID magnetometer.
Paramagnetism is due to the presence of unpaired electrons in the material, so most atoms with incompletely filled atomic orbitals are paramagnetic, although exceptions such as copper exist. Due to their spin, unpaired electrons have a magnetic dipole moment and act like tiny magnets. An external magnetic field causes the electrons' spins to align parallel to the field, causing a net attraction. Paramagnetic materials include aluminum, oxygen, titanium, and iron oxide (FeO). Therefore, a simple rule of thumb is used in chemistry to determine whether a particle (atom, ion, or molecule) is paramagnetic or diamagnetic: If all electrons in the particle are paired, then the substance made of this particle is diamagnetic; If it has unpaired electrons, then the substance is paramagnetic.
Piezoelectricity is the electric charge that accumulates in certain solid materials (such as crystals, certain ceramics, and biological matter such as bone, DNA and various proteins) in response to applied mechanical stress. The word piezoelectricity means electricity resulting from pressure and latent heat. It is derived from the Greek word πιέζειν; piezein, which means to squeeze or press, and ἤλεκτρον ēlektron, which means amber, an ancient source of electric charge. French physicists Jacques and Pierre Curie discovered piezoelectricity in 1880.
The piezoelectric effect results from the linear electromechanical interaction between the mechanical and electrical states in crystalline materials with no inversion symmetry. The piezoelectric effect is a reversible process: materials exhibiting the piezoelectric effect (the internal generation of electrical charge resulting from an applied mechanical force) also exhibit the reverse piezoelectric effect, the internal generation of a mechanical strain resulting from an applied electrical field. For example, lead zirconate titanate crystals will generate measurable piezoelectricity when their static structure is deformed by about 0.1% of the original dimension. Conversely, those same crystals will change about 0.1% of their static dimension when an external electric field is applied to the material. The inverse piezoelectric effect is used in the production of ultrasonic sound waves.
Physiological coherence is associated with a sine wave-like pattern in the heart rhythms, increased heart/brain synchronization and entrainment between diverse physiological systems. When the physiological coherence mode is driven by a positive psychological state, we call it psychophysiological coherence.
Studies conducted across diverse populations have associated the use of techniques that increase psychophysiological coherence with a range of favorable outcomes, including reduced anxiety and depression, enhanced cognitive performance, reduced physical stress symptoms, reduced cortisol and increased DHEA. Additionally, practice of these interventions has been associated with reduced depression and improved functional capacity in patients with congestive heart failure, the restoration of normal blood pressure levels in hypertensive individuals, and improved glycemic control and quality of life in patients with diabetes.
In physics, a quantum (plural quanta) is the minimum amount of any physical entity (physical property) involved in an interaction. For example, a photon is a single quantum of light (or of any other form of electromagnetic radiation).
Quantization is one of the foundations of the much broader physics of quantum mechanics. Quantization of energy and its influence on how energy and matter interact (quantum electrodynamics) is part of the fundamental framework for understanding and describing nature.
In physics, resonance describes the phenomenon of amplification that occurs when the frequency of a periodically applied force is in harmonic proportion to a natural frequency of the system on which it acts. When an oscillating force is applied at a resonant frequency of a dynamical system, the system will oscillate at a higher amplitude than when the same force is applied at other, non-resonant frequencies.
Resonance phenomena occur with all types of vibrations or waves: there is mechanical resonance, acoustic resonance, electromagnetic resonance, nuclear magnetic resonance (NMR), electron spin resonance (ESR) and resonance of quantum wave functions. Resonant systems can be used to generate vibrations of a specific frequency (e.g., musical instruments), or pick out specific frequencies from a complex vibration containing many frequencies (e.g., filters).
Example: Schumann Resonance frequencies
Reductionism is any of several related philosophical ideas regarding the associations between phenomena which can be described in terms of other simpler or more fundamental phenomena.
The Oxford Companion to Philosophy suggests a three part division:
Ontological reductionism: a belief that the whole of reality consists of a minimal number of parts.
Methodological reductionism: the scientific attempt to provide explanation in terms of ever smaller entities.
Theory reductionism: the suggestion that a newer theory does not replace or absorb an older one, but reduces it to more basic terms. Theory reduction itself is divisible into three parts: translation, derivation and explanation.
Reductionism can be applied to any phenomenon, including objects, problems, explanations, theories, and meanings.
For the sciences, application of methodological reductionism attempts explanation of entire systems in terms of their individual, constituent parts and their interactions. For example, the temperature of a gas is reduced to nothing beyond the average kinetic energy of its molecules in motion. Thomas Nagel speaks of 'psychophysical reductionism' (the attempted reduction of psychological phenomena to physics and chemistry), as do others and 'physico-chemical reductionism' (the attempted reduction of biology to physics and chemistry), again as do others. In a very simplified and sometimes contested form, such reductionism is said to imply that a system is nothing but the sum of its parts. However, a more nuanced opinion is that a system is composed entirely of its parts, but the system will have features that none of the parts have (which, in essence is the basis of emergentism). "The point of mechanistic explanations is usually showing how the higher-level features arise from the parts."
Ultra high frequencies, between 300 and 1000 MHz Example: GSM, Government communications, short range radar